Why should I take the test?💡

A double marker test is not a definitive test. Instead, it's classified as a predictive test because it can determine any chromosomal malformation in the fetus. Although the screening is not mandatory, it is highly recommended if you are over the age of 35 or you have a family history of certain conditions. The result of the test only tells you there is a heightened risk of trisomies but it doesn't specify any abnormalities. 

Chromosomal abnormalities can result in serious developmental deformities and health complications such as Down's syndrome or Edward's syndrome. Knowing possible abnormalities can help you manage your pregnancy and prepare for the potential that you will have a child that needs special care.

How is the test done?💉 

There is a relatively slim time window to conduct a double marker test. Generally the procedure is performed sometimes between the gestational age of 11 and 14 weeks.

The test is done with an ultrasound test and a blood sample, screening for blood levels of both free beta-human chorionic gonadotropin (beta - hCG) and pregnancy - associated plasma protein A (PAPP-A). It does not require any preparations. The doctor will contact you near the end of your first trimester or very early in the second trimester. 

TMI from Baby Billy👩‍⚕️:   

Trisomy - chromosomal abnormality

A trisomy is a chromosomal condition in which there are three chromosomes instead of the usual pair of chromosomes. One of the most common trisomy, trisomy 21, or Down's syndrome occurs when the baby has three #21 chromosomes.

Other trisomies that signify fatal genetic birth disorders are trisomy 18 and trisomy 13. Trisomy 18 is often related to Edward's syndrome. Trisomy 13 can result in Patau's syndrome. 

Standard results for the double marker test

When you receive your result, you can see screen positive, high risk and screen negative. Screen negative is considered a normal result, meaning your baby will not be likely to have chromosomal abnormalities. On the other hand, screen positive means your baby has a high potential of chromosomal abnormalities.

If your result is in the normal range, you will be recommended to do further testing if the doctor thinks it's necessary after considering other indicators such as family medical history or age.

Positive results for the double marker test

The results of the test allows you to make important decisions about further testing, medical treatment, mental preparation and the overall management of your pregnancy and delivery. If your screening comes back with a screen positive result, you can go over the result with a genetic counselor. You can also choose to confirm the result again with more invasive tests, such as noninvasive prenatal testing (NIPT), amniocentesis, or chorionic villous sampling.